Lori,
We stayed in the Holiday inn, it worked out great for our family. It wasn't in the heart of everything but the bus that stopped right by the hotel took us everywhere we needed to get to without incurring the expense of parking and high hotel rates. The people at the front desk were very helpful, sold bus tickets there, grocery store just down the street. Here is the link to it
http://www.holidayinn.com/hotels/us/en/florence/flnit/hoteldetail?cm_mmc=mdpr-_-googlemapsit-_-hi-_-flnit